Evidence map›Paper›PMID 41174258›Full record

ReviewCurrent oncology reports2025

Beyond Standard Radiotherapy: an AI-Driven Framework for Personalized Radiotherapy with a Four-Step Classification in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients.

Yongxin Guo, Eric O Aboagye, Dorothy M Gujral

Abstract readReview
In one paragraph

Review in Current oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yongxin GuoDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0NN, United Kingdom.
Eric O AboagyeDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0NN, United Kingdom.
Dorothy M GujralDepartment of Radiotherapy, Imperial College Healthcare NHS Trust, London, W6 8RF, United Kingdom. d.gujral@nhs.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewRadiotherapy (RT) is a mainstay treatment strategy for patients with radically treatable head and neck cancer (HNC). Efforts to personalize RT have spanned decades, yielding variable results across different treatment stages. The purpose of this review was to assess the potential of AI-driven models to bridge personalized radiotherapy strategies. RECENT

findingsRadiomics, an emerging imaging analytics approach, provides significant quantitative features that can predict survival outcomes, treatment responses, and radiation-induced toxicity. Radiomics-based models in the studies demonstrate promising predictive efficacy with a high C-index or area under the curve (AUC) exceeding 0.70. AI-driven multimodal and multitemporal imaging models can stratify patients and guide risk-adapted radiotherapy. A four-step AI-driven RT framework may provide a template for future randomized controlled trials, supporting more trustworthy evidence.

Indexed as

Artificial IntelligenceHead and Neck NeoplasmsPrecision MedicineSquamous Cell Carcinoma of Head and NeckHumansRadiotherapy Planning, Computer-AssistedAI-driven radiotherapyHead and neck squamous cell carcinomaPersonalized radiotherapyRadiomicsSpatiotemporal imaging

Identifiers

PMID41174258
PMCPMC12698768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.