Evidence map›Paper›PMID 41174248›Full record

ArticleNeuroscience bulletin2025

Hierarchical Replay of Multi-regional Sequential Spiking Associated with Working Memory.

Ermeng Huang, Da Xu, Huangao Zhu, Zhaoqin Chen, Yulei Chen, Shujun Lei, Jiawei Liu, Chengyu T Li, Xiaoxing Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ermeng Huang *Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Da Xu *Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Huangao Zhu *Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhaoqin ChenShanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, 200031, China.
Yulei ChenInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Shujun LeiShanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, 200031, China.
Jiawei LiuInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Chengyu T LiInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. tonylicy@lglab.ac.cn.
Xiaoxing ZhangShanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, 200031, China. xiaoxing.zhang@lglab.ac.cn.ORCID https://orcid.org/0000-0001-5229-6091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How do millisecond-scale neural activities mediate second-scale behaviors? We recorded brain-wide activity in mice performing an olfactory working-memory task to decipher the cross-region organization of activity. Spike-correlograms analysis revealed millisecond within- and cross-region spike couplings, which were enriched among memory-encoding neurons with similar odor preferences. Spike coupling linked neurons into motifs of chains, single loops, and nested loops, especially among hippocampal and prefrontal-cortex neurons. Spike-coupling direction and activity-chain propagation aligned with that of memory-associated activity waves. Intriguingly, activity motifs were replayed before and after task performance, and during inter-trial intervals. Motifs exhibited hierarchical organization, with progressively longer time constants and the number of participating neurons. Thus, hierarchically organized and replayed cross-region spiking motifs are modulated on demand during the delay period, providing a potential mechanism for perceptual working-memory maintenance.

Indexed as

Activity loopActivity waveFunctional couplingGlobal dynamic hierarchyNeuropixelsReplaySynfire chainWorking memory

Identifiers

PMID41174248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.