Evidence map›Paper›PMID 41174214›Full record

ArticleScientific reports2025

Targeting KRAS

Tonia Kirschner, João Rodriguez, Emerson Gonçalves Moreira, Janina Niggenaber, Jonas D Warmuth, Hugo Verli, Matthias P Müller, Daniel Rauh

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mechanisms and current advances in treatingChinese medical journal pulmonary and critical care medicine · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tonia KirschnerDepartment of Chemistry and Chemical Biology, Drug Discovery Hub Dortmund (DDHD), TU Dortmund University, Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.
João RodriguezPrograma de Pos-Graduacao em Biologia Celular e Molecular (PPGBCM), Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Goncalves, Porto Alegre, 9500, CEP 91501-970, RS, Brazil.
Emerson Gonçalves MoreiraPrograma de Pos-Graduacao em Biologia Celular e Molecular (PPGBCM), Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Goncalves, Porto Alegre, 9500, CEP 91501-970, RS, Brazil.
Janina NiggenaberDepartment of Chemistry and Chemical Biology, Drug Discovery Hub Dortmund (DDHD), TU Dortmund University, Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.
Jonas D WarmuthDepartment of Chemistry and Chemical Biology, Drug Discovery Hub Dortmund (DDHD), TU Dortmund University, Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.
Hugo VerliPrograma de Pos-Graduacao em Biologia Celular e Molecular (PPGBCM), Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Goncalves, Porto Alegre, 9500, CEP 91501-970, RS, Brazil. hugoverli@gmail.com.
Matthias P MüllerDepartment of Chemistry and Chemical Biology, Drug Discovery Hub Dortmund (DDHD), TU Dortmund University, Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany. matthias3.mueller@tu-dortmund.de.
Daniel RauhDepartment of Chemistry and Chemical Biology, Drug Discovery Hub Dortmund (DDHD), TU Dortmund University, Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany. daniel.rauh@tu-dortmund.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The small GTPase KRAS is a key driver of carcinogenesis when mutated, and significant progress has been made in targeting KRAS

Indexed as

Proto-Oncogene Proteins p21(ras)Crystallography, X-RayHumansKineticsModels, MolecularMutationProtein BindingStructure-Activity RelationshipKRAS protein, humanProto-Oncogene Proteins p21(ras)Computer-aided drug designG13CKRASNucleotide-based inhibitors

Identifiers

PMID41174214
PMCPMC12578930

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.