ArticleEuropean radiology experimental2025
Prospective UTE two-component MRI analysis of graft ligamentization after ACL reconstruction and association with demographic and surgical factors.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWe aimed to evaluate longitudinal changes in ultrashort echo time (UTE) two-component biomarkers reflecting graft ligamentization after anterior cruciate ligament (ACL) reconstruction and to identify associated clinical factors. MATERIALS AND
methodsPatients who underwent ACL reconstruction were prospectively included to perform 3-T three-dimensional double-echo UTE sequence at 3, 6, and 12 months postoperatively. Mean values of short T2* (T2*
resultsForty-two patients (20 males), aged 32.7 ± 15.0 years (mean ± standard deviation), were enrolled. T2*
conclusionUTE two-component analysis captures temporal changes in graft after ACL reconstruction, suggesting collagen regeneration. Higher BMI may hinder, while STG grafts and remnant preservation may promote ligamentization. RELEVANCE STATEMENT: UTE two-component analysis serves as an imaging biomarker for ACL graft ligamentization, with higher BMI being associated with impaired ligamentization, while the use of STG grafts and remnant preservation may be associated with more favorable graft maturation at 12 months as assessed by UTE two-component MRI. These findings may help tailor rehabilitation protocols and guide graft selection.
trial registrationThis study was prospectively registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) under the identification number UMIN000045710 in October 2021. KEY POINTS: Ultrashort echo time two-component analysis noninvasively evaluates ligamentization of reconstructed ACL. Graft short T2* significantly decreased between 6 and 12 months postoperatively. Body mass index, graft type, and remnant status may influence graft maturation at 12 months.
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