ArticleNature microbiology2025
Taxonomic expansion and reorganization of Flaviviridae.
Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Alignment-freeJournal of clinical microbiology · 2026Article
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- Detection and phylogenetic characterization of Jingmen tick virus inMicrobiology spectrum · 2026Article
- Identification and geographic evolutionary analysis of human pegivirus infection based on metatranscriptomic sequencing.Virologica Sinica · 2026Article
- Mapping Determinants of Hepatitis C Virus E1/E2 Transmembrane Interactions Using Intergenotypic Chimeras.Viruses · 2026Article
- Virus taxonomy and the ICTV - 21 FAQs for the perplexed virologist.The Journal of general virology · 2026Review
- Benchmarks for taxonomic classification of jingmenviruses and closely related viruses using newly identified genomic sequences.The Journal of general virology · 2026Article
- Genomic Surveillance of BVDV in Southern Brazil: What Changed After a Decade in Rio Grande do Sul?Viruses · 2026Article
- Revealing deep evolutionary relationships between RNA viruses using predicted structural models of viral RNA polymerases.Molecular biology and evolution · 2026Article
- Integrating metagenomics and metatranscriptomics intoThe Journal of general virology · 2026Review
- Amarilloviruses of Aquatic Animals.Pathogens (Basel, Switzerland) · 2026Review
- Molecular characterization and geographic incidence of two pestiviruses infecting the corn leafhopper (Dalbulus maidis) in the United States.Archives of virology · 2026Article
- Tick-Borne Encephalitis in the 21Le infezioni in medicina · 2026Review
- Evaluation of an E2-based indirect ELISA for the serological differentiation of ovine Italy pestivirus from classical swine fever virus in pigs.Frontiers in veterinary science · 2026Article
- Comprehensive hallmark gene sequence, genomic and structural analysis clarifies new and established taxa within theVirus evolution · 2026Article
- HoBi-Like Pestivirus Is the Most Frequently Detected Pestivirus in Cattle Across Different Regions of Brazil.Transboundary and emerging diseases · 2026Article
- First Identification, Recombinant Production, and Structural Characterization of a Putative Structural Protein from the Haseki Tick Virus Polyprotein.Biomolecules · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Flaviviridae is a family of non-segmented positive-sense RNA viruses that includes major pathogens such as hepatitis C virus, dengue viruses and yellow fever virus. Recent large-scale metagenomic surveys have identified many RNA viruses related to members of this family, such as orthoflaviviruses and pestiviruses. These viruses diverge by having different genome lengths and configurations, and host range. Here we performed an analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences of flaviviruses and 'flavi-like' viruses. We uncovered four divergent clades and multiple lineages that are congruent with phylogenies of their helicase genes, protein profile hidden Markov model profiles, and evolutionary relationships based on predicted RdRP protein structures. These results support their classification into three families (Flaviviridae, Pestiviridae and Hepaciviridae) and 12 genera in the established order Amarillovirales, with groupings correlating with genome properties and host range. This taxonomy provides a framework for future evolutionary studies on this important viral family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.