ArticleCommunications biology2025
Large-scale audiometric phenotyping identifies distinct genes and pathways involved in hearing loss subtypes.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Precision Phenotyping With Audiometric Data and Gene Discovery for Sensorineural Hearing Loss.JAMA otolaryngology-- head & neck surgery · 2026Article
- Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults.American journal of human genetics · 2026Article
- Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults from the CLSA.bioRxiv : the preprint server for biology · 2026Article
- Short tandem repeats significantly contribute to the genetic architecture of metabolic and sensory age-related hearing loss phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives.Journal of xenobiotics · 2026Review
- Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss.Frontiers in molecular neuroscience · 2026Review
- Association Between Age-Related Sensory and Metabolic Hearing Loss and Cognitive Performance.Trends in hearingArticle
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Funding
Abstract
Age-related hearing loss affects one-third of the population over 65 years. However, the diverse pathologies underlying these heterogeneous phenotypes complicate genetic studies. Here we show that by applying computational phenotyping approaches based on audiometrically measured hearing loss, we can overcome challenges associated with accurate phenotyping for older adults with hearing loss. Using this phenotyping strategy, we uncover differences in the associations observed between genetic variants and sensory and metabolic hearing loss. Sex-stratified analyses of these sexually dimorphic hearing loss phenotypes reveal a locus of relevance to sensory hearing loss in males, but not females. Enrichment analyses implicate genes involved in frontotemporal dementia in metabolic hearing loss, while genes relating to sensory processing of sound by hair cells are implicated in sensory hearing loss. Our study enhances our understanding of these two hearing loss phenotypes, representing the first step in the development of more precise treatments for these pathologically distinct hearing loss phenotypes.
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