SynthesisBrain imaging and behavior2025
Transcriptomic signatures of gray matter volume alterations in hepatic encephalopathy.
Synthesis in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been revealed that brain gray matter volume (GMV) abnormalities are present in patients with hepatic encephalopathy (HE). However, the GMV alterations in HE that have been uncovered are inconsistent, and their correlation with gene expression profiles is still unknown. We conducted a quantitative neuroimaging meta-analysis on seven studies, involving 142 HE individuals and 193 HCs, to identify consistent patterns of GMV alterations in HE. We then utilized the Allen Human Brain Atlas database to investigate transcriptome-neuroimaging spatial correlations, exploring gene expression profiles related with GMV changes in HE. Functional enrichment analyses were further performed to identify biological significance of the GMV-related genes. Compared with healthy controls, patients with HE exhibited decreased GMV primarily in the bilateral cerebellum, basal nuclei, insula, cingulate / paracingulate gyri (the anterior and the median), superior frontal gyrus (medial), precuneus and right inferior frontal gyrus. While the GMV of bilateral thalamus and right lingual gyrus were observed to increase in HE patients. Moreover, we revealed spatial associations between brain structural changes and transcriptional profiles of 2035 genes, which were enriched in specific biological processes in HE. Our findings improved the understanding of GMV abnormalities in HE and provided insights into the transcriptional expression patterns underlying these alterations.
Indexed as
Identifiers
41174127What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.