Evidence map›Paper›PMID 41174118›Full record

ArticleVeterinary research communications2025

Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus).

Orhan Corum, Duygu Durna Corum, Pedro Marin, Onder Yildirim, Ertugrul Terzi, Ruby C Gonzales, Dan M Arriesgado, Victor R Navarro, Soner Bilen, Adem Yavuz Sonmez and 1 more

Abstract read
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In one paragraph

Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Orhan CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Antakya, Hatay, 31060, Türkiye. orhancorum46@hotmail.com.
Duygu Durna CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Antakya, Hatay, 31060, Türkiye.
Pedro MarinDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Murcia, 30100, Spain.
Onder YildirimDepartment of Aquaculture, Faculty of Fisheries, Mugla Sıtkı Kocman University, Mugla, 48000, Türkiye.
Ertugrul TerziDepartment of Veterinary Medicine, Devrekani TOBB Vocational School, University of Kastamonu, Kastamonu, 37200, Türkiye.
Ruby C GonzalesCollege of Science and Environment, Department of Marine Biology and Environmental Science, Mindanao State University Naawan, Naawan, Misamis Oriental, 9023, Philippines.
Dan M ArriesgadoFaculty of Fisheries, Department of Fisheries, Mindanao State University Naawan, Naawan, Misamis Oriental, 9023, Philippines.
Victor R NavarroFaculty of Fisheries, Department of Fisheries, Mindanao State University Naawan, Naawan, Misamis Oriental, 9023, Philippines.
Soner BilenDepartment of Veterinary Medicine, Ihsangazi Vocational School, University of Kastamonu, Kastamonu, 37200, Türkiye.
Adem Yavuz SonmezInebolu Vocational School, University of Kastamonu, Kastamonu, 37200, Türkiye.
Kamil UneyDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, 42031, Türkiye.

Funding

The Coordination of Scientific Research Projects, University of Kastamonu KU-BAP01/2018-99
6 · The paper itself

Abstract

Cefuroxime is a broad-spectrum antibiotic extensively utilized in humans and animals. Although it has been reported as beneficial against certain fish infections, pharmacokinetic studies are lacking. The purpose of this study was to evaluate the pharmacokinetics of cefuroxime following intravascular (IV, n = 72), intraperitoneal (IP, n = 72), intramuscular (IM, n = 72), and oral (n = 72) administration of 20 mg/kg in Nile tilapia (Oreochromis niloticus) maintained at 29 ± 1.5 °C. Two hundred and eighty-eight fish were equally distributed among four treatment groups: IV, IP, IM, and oral. Blood samples were obtained from 6 fish per group at 12 distinct time intervals over a duration of 96 h. Cefuroxime plasma concentrations were quantified with high-performance liquid chromatography and subsequently evaluated through non-compartmental analysis. Following IV injection, the t

Indexed as

Anti-Bacterial AgentsCefuroximeCichlidsAdministration, OralAnimalsBiological AvailabilityInjections, IntramuscularInjections, IntraperitonealAnti-Bacterial AgentsCefuroximeCefuroximeDifferent routesNile tilapiaPharmacokinetic

Identifiers

PMID41174118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.