Evidence map›Paper›PMID 41174106›Full record

ArticleSkeletal radiology2026

Diagnostic efficacy of pediatric image-guided core needle biopsy of musculoskeletal lesions.

Winston L Winkler, Jonathan C Baker, Anderanik Tomasian, Benjamin Northrup, Theodore L Vander Velde, Travis J Hillen, Chongliang Luo, Resten Imaoka, Gino M Dettorre, Jack W Jennings

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Article in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Winston L WinklerDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA. winstonwinkler@wustl.edu.ORCID http://orcid.org/0000-0002-6795-2597
Jonathan C BakerDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA.
Anderanik TomasianDepartment of Radiology, Section of Musculoskeletal Radiology, University of Southern California, 1441 Eastlake Ave, Los Angeles, CA, 90089, USA.
Benjamin NorthrupDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA.
Theodore L Vander VeldeDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA.
Travis J HillenDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA.
Chongliang LuoDivision of Public Health Sciences, Washington University School of Medicine in St. Louis, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Resten ImaokaDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA.
Gino M DettorreDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA.
Jack W JenningsDepartment of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the diagnostic success of image-guided core needle biopsy (ICNB) of bone and soft tissue lesions in the pediatric population and what factors influence diagnostic success.

methodsFor 370 biopsies performed on 350 patients 18 years of age and younger, the diagnostic yield (proportion of biopsies histopathologically sufficient for diagnosis) and accuracy (proportion of biopsies in which ICNB specimen concordant with the reference standard histopathology from surgical excision) of the biopsies, as well as a series of patient, lesion-related, and technical factors, were retrospectively analyzed. Multivariate statistical analysis was performed to evaluate what factors predicted diagnostic yield and accuracy.

resultsDiagnostic yield was 95.1% (213/224) for bone biopsies and 97.1% (132/136) for soft tissue biopsies. Diagnostic accuracy was 93.1% (27/29) for bone biopsies and 88.4% (38/43) for soft tissue biopsies. Lesions of suspected benign etiology were found to be associated with lower diagnostic yield (OR = 15.2, p = 0.002) for bone biopsies, and increased total core length (OR = 3.3, p = 0.047) was found to be associated with higher yield for soft tissue biopsies. Increased needle gauge (OR = 2.9, p = 0.03) was found to be associated with higher accuracy for bone biopsies, and using a manual drill (compared to a battery-powered drill) was associated with lower accuracy (OR = 0.03, p = 0.03). Overall, 88.9% (32/36) of samples from the biopsy were sufficient for additional cytogenetic analysis. Complications occurred in 0.3% (1/370) of biopsies.

conclusionsICNB has a high rate of diagnostic success and a low complication rate and should be considered an alternative to open biopsy.

Indexed as

Bone NeoplasmsImage-Guided BiopsySoft Tissue NeoplasmsAdolescentBiopsy, Large-Core NeedleChildChild, PreschoolFemaleHumansInfantMaleReproducibility of ResultsRetrospective StudiesBiopsyBone-biopsyDiagnostic efficacyDiagnostic yieldPediatricsSoft-tissue biopsy

Identifiers

PMID41174106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.