Evidence map›Paper›PMID 41174098›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Refining the clinical utility of [

Liam Widjaja, Johannes Hornfeck, Sophie C Siegmund, Franz J Gildehaus, Nina-Sophie Schmidt-Hegemann, Vera Wenter, Gabriel T Sheikh, Konrad Klimek, Jozefina Casuscelli, Christian G Stief and 2 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Beyond [BMC cancer · 2026
    Pooled it
  2. Review
  3. Progress in the application ofAnnals of nuclear medicine · 2026
    Review
  4. Review
  5. Review
  6. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liam WidjajaDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany. Liam.Widjaja@med.uni-muenchen.de.ORCID 0000-0002-0243-9338
Johannes HornfeckDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.
Sophie C SiegmundDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.
Franz J GildehausDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.
Nina-Sophie Schmidt-HegemannDepartment of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Vera WenterDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.
Gabriel T SheikhDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.
Konrad KlimekDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.
Jozefina CasuscelliDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Christian G StiefDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Mathias J ZacherlDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.
Rudolf A WernerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, D-81377, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([

methodsThis retrospective, single-center study included 23 patients with mCRPC who underwent Fluor-18 ([

resultsFollowing two cycles of tandem RLT, 11 patients (48%) achieved a PR. The treatment was generally tolerated well. Grade 3 events included renal impairment in two (9%) and grade 3 anemia in five (22%) patients, while no Grade 4/5 events occurred. Patients with increased PSMA expression on pretherapeutic PET (defined by the average mean standardized uptake value of all tumor lesions [SUV

conclusion[

Indexed as

ActiniumLutetiumProstatic Neoplasms, Castration-ResistantAgedAged, 80 and overHumansMaleMiddle AgedNeoplasm MetastasisPositron Emission Tomography Computed TomographyRadioisotopesRadiopharmaceuticalsRetrospective StudiesTreatment OutcomeActiniumActinium-225LutetiumLutetium-177RadioisotopesRadiopharmaceuticalsProstate cancerPSMA-RLTTandem RLTTargeted alpha therapy

Identifiers

PMID41174098
PMCPMC12920758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.