Evidence map›Paper›PMID 41174093›Full record

ArticlePsychopharmacology2026

The sensitivity of adult zebrafish to clinically relevant neuroactive (sedative) effects of extracts of selected traditional Chinese medicine herbs.

Dongmei Wang, Longen Yang, David S Galstyan, Murilo S de Abreu, Allan V Kalueff

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Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dongmei WangDepartment of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Longen YangDepartment of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.
David S GalstyanInstitute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia.
Murilo S de AbreuGraduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil. abreu_murilo@hotmail.com.ORCID http://orcid.org/0000-0001-5562-0715
Allan V KalueffDepartment of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China. avkalueff@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleTraditional Chinese Medicine (TCM) continues to play an important role in modern medicine. TCM herbs are commonly used to treat various brain disorders, including anxiety and depression. Complementing rodent studies, the zebrafish (Danio rerio) has emerged as a promising new model organism for modeling brain disorders and neuroactive drug discovery.

objectivesThe present study aimed to develop adult zebrafish-based screens to test potential neurotropic effects of water extracts of selected neuroactive TCM herbs.

methodsZebrafish behavior was tested in 5-min novel tank and light-dark box tests following acute 20-min exposure to various concentrations of water extracts of ginseng, saffron, St. John's wort, lavender, passiflora and albizia, chosen here for their well-known therapeutic anxiolytic/sedative effects clinically and in rodent models.

resultsAll TCM extracts tested evoked overt dose-dependent sedative-like effects in zebrafish in both behavioral tests, consistent with their neuroactive profiles known clinically.

conclusionsCollectively, our study demonstrates high sensitivity of zebrafish to neuroactive effect of TCM herbs, suggesting these fish as a valid, promising, feasible and clinically relevant screen for studying neurotropic activity of TCM herbs in-vivo.

Indexed as

Behavior, AnimalDrugs, Chinese HerbalHypnotics and SedativesPlant ExtractsAnimalsDose-Response Relationship, DrugMaleMedicine, Chinese TraditionalZebrafishDrugs, Chinese HerbalHypnotics and SedativesPlant ExtractsCNS drugsPreclinical screeningSedative effectsTraditional Chinese medicinesZebrafish models

Identifiers

PMID41174093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.