Evidence map›Paper›PMID 41174046›Full record

ArticleScientific reports2025

IMT504 accelerates post-hepatectomy liver regeneration in mice with involvement of GLAST + Wnt1 + bone marrow stromal progenitors.

Maximiliano Borda, Lucía Cafaro, Romina Sierra, Mercedes Díaz Pedraza, Camila Becerra, Agustina Ábalo, María José Karolewski, María José Cantero, Máximo Schiavone, Guillermo D Mazzolini and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maximiliano BordaDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
Lucía CafaroDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
Romina SierraDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
Mercedes Díaz PedrazaDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
Camila BecerraDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
Agustina ÁbaloDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
María José KarolewskiHospital Universitario Austral, Buenos Aires, Argentina.
María José CanteroFacultad de Ciencias Biomédicas, Universidad Austral, Buenos Aires, Argentina.
Máximo SchiavoneDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
Guillermo D MazzoliniFacultad de Ciencias Biomédicas, Universidad Austral, Buenos Aires, Argentina.
Alejandro MontanerInstituto de Ciencia y Tecnología Dr. César Milstein, Fundación Pablo Cassará, Buenos Aires City, Argentina.
Esteban J FioreDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina. efiore@austral.edu.ar.
Jorge B AquinoDevelopmental Biology & Regenerative Medicine Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET-Universidad Austral, Av. Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina. jaquino@austral.edu.ar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunomodulatory oligodeoxynucleotide (ODN) IMT504 exhibits antifibrotic and pro-regenerative properties in the context of liver fibrosis. It also enhances the contribution of GLAST

Indexed as

HepatectomyLiver RegenerationMesenchymal Stem CellsWnt1 ProteinAnimalsCell DifferentiationCell ProliferationHepatocytesLiverMaleMiceWnt1 ProteinWnt1 protein, mouseBone marrow stromal progenitorsDevelopmental plasticityDifferentiationEndothelial cellsHepatocytesProliferationRegenerative medicine

Identifiers

PMID41174046
PMCPMC12578784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.