ArticleScientific reports2025
TET1 modulates trophoblast function by regulation of ODC1 in preeclampsia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Preeclampsia (PE) is a pregnancy-specific disease that seriously endangers the health of the pregnant woman and the fetus. DNA hydroxymethylation, an epigenetic modification, plays crucial roles in the development of PE. However, the molecular mechanism remains to be elucidated. TET1 is a DNA demethylase that regulates placental trophoblast function. Herein, we investigated the role of TET1 in PE occurrence. Firstly, we confirmed that the 5-methylcytosine (5-mC) levels were reduced in placental tissues from human PE patients and a mouse PE model, while TET1 expression was upregulated. In an oxidative stress model of HTR8/SVneo cells, knockdown of TET1 partially restored the impaired cell invasion and migration caused by H
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