ArticleScientific reports2025
Univariate and multivariate signal processing spectrophotometric determination of an antihypertensive combination in line with the United Nations sustainable development goals.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A novel electrochemical sensor based on Al-doped ZnO nanoparticles-modified carbon paste electrode for ivabradine sensitive monitoring in human plasma.Analytical and bioanalytical chemistry · 2026Article
- Toward sustainable diagnostics forRSC advances · 2026Review
- Chemometric-assisted spectrophotometric approach for stability assessment of safinamide and its synthetic precursor in antiparkinsonian formulation with sustainability profiling.Scientific reports · 2025Article
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5 authors.
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Abstract
Effective management of hypertension typically involves multiple medications. This underscores the pharmaceutical industry's demand for simple, cost-effective, and environmentally sustainable analytical methods capable of handling complex, multicomponent formulations. This study's primary goal was to compare and validate univariate and multivariate spectrophotometric techniques for analyzing fixed-dose antihypertensive formulations of Telmisartan (TEL), Chlorthalidone (CHT), and Amlodipine (AML). Successive Ratio Subtraction paired with Constant Multiplication (SRS-CM) and Successive Derivative Subtraction paired with Constant Multiplication (SDS-CM) were the developed univariate methods. The cited drugs were successfully quantified at their respective maxima: 295.7 nm for TEL, 275.0 nm for CHT, and 359.5 nm for AML. On the other hand, the SDS-CM method enabled their determination using first-derivative spectra, with TEL identified at P
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