Evidence map›Paper›PMID 41173974›Full record

ArticleScientific reports2025

Parental major life events before or during pregnancy and autistic behaviors among preschool children.

Weiying Liu, Yulan Wu, Dongyan Wen, Huiting Chen, Jinming Liu, Shuang Wu, Jiarong Lin, Zizi Liu, Xuanshu Wang, Lvping Li and 3 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Weiying Liu *Department of Epidemiology, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.
Yulan Wu *Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China.
Dongyan Wen *Department of Rehabilitation, The Third People's Hospital of Huizhou City, Huizhou, 516000, China.
Huiting ChenDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China.
Jinming LiuDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China.
Shuang WuDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China.
Jiarong LinDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China.
Zizi LiuDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China.
Xuanshu WangDepartment of Epidemiology, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.
Lvping LiDepartment of Rehabilitation, The Third People's Hospital of Huizhou City, Huizhou, 516000, China.
Feixiang ZengDepartment of Rehabilitation, The Third People's Hospital of Huizhou City, Huizhou, 516000, China. 52533824@qq.com.
Ruoqing ChenDepartment of Epidemiology, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China. chenrq28@mail.sysu.edu.cn.
Yu JinDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China. jinyu@mail.sysu.edu.cn.

Funding

100 Talents Plan Foundation of Sun Yat-sen University 58000-12230022Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515110417Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515012442China Disabled Persons' Federation Special Project Foundation 2022CDPFHS-13Guangzhou Civil Affairs Science and Technology Foundation 2022MZK02Huizhou Committee of Chinese People's Political Consultative Conference HT-99982022-0032Shenzhen Science and Technology Program 202206193000001
6 · The paper itself

Abstract

In this study, we aimed to examine whether parental major life events before or during pregnancy were associated with autistic behaviors in preschoolers, and whether alcohol use or smoking modified these associations. This study included 18,664 children aged 3-6 years in southern China. Parents reported seven types of major life events before or during pregnancy. Autistic behaviors were assessed by the Clancy Autism Behavior Scale. Logistic regression was applied to evaluate the associations of parental major life events with the risk of autistic behaviors, along with the modifying effects of alcohol consumption and smoking. This study found that paternal exposure to major life events before or during pregnancy was associated with an increased risk of autistic behaviors. Maternal exposure to major life events during pregnancy was associated with a higher risk of autistic behaviors. The associations between paternal pre-pregnancy major life events and autistic behaviors were stronger when either parent consumed alcohol before pregnancy. No modifying effect was shown for smoking. Findings from this study highlighted the importance of monitoring parental stress and alcohol use before and during pregnancy to improve children's neurodevelopmental outcomes.

Indexed as

Autistic DisorderLife Change EventsParentsPrenatal Exposure Delayed EffectsAdultAlcohol DrinkingChildChild, PreschoolChinaFemaleHumansMalePregnancyRisk FactorsSmokingAlcohol consumptionAutistic behaviorsMajor life eventsPreschool childrenSmoking

Identifiers

PMID41173974
PMCPMC12578796

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