Trial reportTranslational psychiatry2025
Therapeutic deep brain stimulation targeting BNST-NAc circuit driven large-scale brain networks in treatment-resistant depression.
Trial report in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Deep brain stimulation mechanisms in comorbid pain and emotional dysregulation from animal models.iScience · 2026Review
- GABAB1R: A molecular bridge linking deep brain stimulation to antidepressant effects--A commentary on "NAcLat-DBS reduces GABAB1R expression of dopamine neurons to correct depressive symptoms in CMS mice".Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Major depressive disorder is associated with reduced intrinsic connectivity between the bed nucleus of the stria terminalis and ventral striatum.Journal of psychiatry & neuroscience : JPN · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic deep brain stimulation (DBS) targeting the striatum shows promise for treatment-resistant depression (TRD), but its effects on large-scale brain network dynamics remain unclear. This study aimed to elucidate how DBS targeting the bed nucleus of the stria terminalis-nucleus accumbens (BNST-NAc) circuit modulates network dynamics, assessed via electroencephalography (EEG) microstates, and how these changes relate to local circuit activity. In a randomized, double-blind, crossover trial with 10 TRD patients, synchronous resting-state scalp EEG and NAc local field potential (LFP) data were collected during active and sham stimulation. Microstate analysis identified five consistent microstates (A-E). Compared to sham, therapeutic DBS increased the coverage and occurrence of microstates A and B. Transition probabilities involving A ⇌ C, E → B, and B → A were increased during active stimulation, whereas C ⇌ D transitions were reduced. Several of these changes, notably the reduced transitions between C and D, were associated with symptom improvements. Critically, time-locked analysis revealed that a significant increase in NAc gamma-band aperiodic activity specifically preceded transitions from microstate C to D, but not from D to C. These findings provide multi-scale mechanistic evidence that BNST-NAc DBS drives clinically relevant EEG microstate alterations in TRD patients, which are driven by specific gamma aperiodic activity patterns in the NAc. Combined EEG-LFP microstate signatures may therefore serve as valuable biomarkers for DBS treatment response.
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