Evidence map›Paper›PMID 41173902›Full record

ArticleScientific reports2025

Identification and validation of prognostic genes associated with m6A-regulated programmed cell death in acute lymphoblastic leukemia.

Jiarui Zhang, Meiru Yan, Juan Liu, Sijia Ma, Haipeng Hu, Man Xu, Min He

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiarui ZhangDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta, Xi'an, Shaanxi, China.ORCID http://orcid.org/0009-0008-1864-4345
Meiru YanDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta, Xi'an, Shaanxi, China.ORCID http://orcid.org/0009-0007-3604-8849
Juan LiuDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta, Xi'an, Shaanxi, China.ORCID http://orcid.org/0009-0005-5742-241X
Sijia MaDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta, Xi'an, Shaanxi, China.ORCID http://orcid.org/0000-0003-1456-3448
Haipeng HuDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta, Xi'an, Shaanxi, China.ORCID http://orcid.org/0009-0001-5075-1107
Man XuDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta, Xi'an, Shaanxi, China.ORCID http://orcid.org/0000-0003-1092-8964
Min HeDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta, Xi'an, Shaanxi, China. hemin219@xjtufh.edu.cn.ORCID http://orcid.org/0000-0002-6494-2190

Funding

Shaanxi Provincial Department of Science and Technology 2025JC-YBMS-1083
6 · The paper itself

Abstract

This study investigated the prognostic significance of m6A-related programmed cell death (PCD) genes in acute lymphoblastic leukemia (ALL). Transcriptomic data from the TCGA-ALL and GSE48558 datasets were analyzed to identify m6A-related PCD genes (corgenes), which were then intersected with 3,063 differentially expressed genes (DEGs), resulting in 23 candidate genes. Univariate Cox regression and LASSO regression analyses identified CFLAR and CDK4 as key prognostic genes, facilitating the construction of a high-accuracy risk prediction model. Gene set enrichment analysis (GSEA) revealed significant pathway differences between the high-risk group (HRG) and the low-risk group (LRG), including olfactory transduction, circadian rhythm, and protein export (adj.P < 0.05). Sensitivity analysis of 60 chemotherapy agents indicated that Bicalutamide was more effective in LRG, while ATRA, CCT018159, PHA-665752, and PLX4720 demonstrated greater efficacy in HRG. RT-qPCR validation confirmed upregulation of CDK4 and downregulation of CFLAR in ALL samples (P < 0.05). This study offers important theoretical support for the prognostic evaluation and personalized treatment strategies in ALL.

Indexed as

ApoptosisPrecursor Cell Lymphoblastic Leukemia-LymphomaBiomarkers, TumorCyclin-Dependent Kinase 4FemaleGene Expression ProfilingGene Expression Regulation, LeukemicHumansMalePrognosisTranscriptomeBiomarkers, TumorCDK4 protein, humanCyclin-Dependent Kinase 4Acute lymphoblastic leukemiaN6-methyladenosinePrognostic genesProgrammed cell deathRisk model

Identifiers

PMID41173902
PMCPMC12578898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.