Evidence map›Paper›PMID 41173862›Full record

ArticleTranslational psychiatry2025

Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity.

A Moses Lee, Audrey Kist, John Alvarez, Kristin K Sellers, Ankit N Khambhati, Leo P Sugrue, Lee B Reid, Kelly Kadlec, Sneha Ray, Joline M Fan and 11 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. A human subcortical connectome at 400 μm resolution.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

A Moses LeeWeill Institute for Neurosciences, University of California, San Francisco, US. andrewmoses.lee@ucsf.edu.ORCID http://orcid.org/0000-0003-0531-102X
Audrey KistWeill Institute for Neurosciences, University of California, San Francisco, US.ORCID http://orcid.org/0000-0001-6428-6616
John AlvarezWeill Institute for Neurosciences, University of California, San Francisco, US.
Kristin K SellersWeill Institute for Neurosciences, University of California, San Francisco, US.ORCID http://orcid.org/0000-0002-0517-2296
Ankit N KhambhatiWeill Institute for Neurosciences, University of California, San Francisco, US.ORCID http://orcid.org/0000-0001-6182-4677
Leo P SugrueWeill Institute for Neurosciences, University of California, San Francisco, US.
Lee B ReidWeill Institute for Neurosciences, University of California, San Francisco, US.
Kelly KadlecWeill Institute for Neurosciences, University of California, San Francisco, US.
Sneha RayWeill Institute for Neurosciences, University of California, San Francisco, US.
Joline M FanWeill Institute for Neurosciences, University of California, San Francisco, US.
Anusha B AllawalaWeill Institute for Neurosciences, University of California, San Francisco, US.
Caroline A RacineWeill Institute for Neurosciences, University of California, San Francisco, US.
Tenzin NorbuWeill Institute for Neurosciences, University of California, San Francisco, US.
Dani AstudilloWeill Institute for Neurosciences, University of California, San Francisco, US.
Alexandra G Tremblay-McGawWeill Institute for Neurosciences, University of California, San Francisco, US.
Natalie BeckerWeill Institute for Neurosciences, University of California, San Francisco, US.
Jessica VerheinWeill Institute for Neurosciences, University of California, San Francisco, US.
Ahmad AlhouraniDepartment of Neurological Surgery, University of California, San Francisco, US.
Philip A StarrWeill Institute for Neurosciences, University of California, San Francisco, US.ORCID http://orcid.org/0000-0003-2733-4003
Edward F Chang *Weill Institute for Neurosciences, University of California, San Francisco, US.ORCID http://orcid.org/0000-0003-2480-4700
Andrew D Krystal *Weill Institute for Neurosciences, University of California, San Francisco, US.ORCID http://orcid.org/0000-0002-6702-781X

Funding

TRAINING THE NEXT GENERATION OF MENTAL HEALTH RESEARCHERSR25MH060482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H MATHALON, Susan M. Voglmaier · 2000 to 2026
$5.2M
Direct Intracranial Electrophysiological Mapping of Insular Circuits for Anxiety in the Human BrainK23MH125018 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, ANDREW MOSES · 2021 to 2025
$1.0M
Targeting DBS Therapy to the OCD Network Using fMRI and Intracranial RecordingsR21MH130914 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, ANDREW MOSES, MORRISON, MELANIE A · 2022 to 2023
$444k
NIMH NIH HHS K23 MH125018NIMH NIH HHS R21 MH130914NIMH NIH HHS R25 MH060482U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH125018U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH130914U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R25MH06048
6 · The paper itself

Abstract

Deep brain stimulation has been used to treat severe, refractory obsessive-compulsive disorder (OCD) with variable outcomes across multiple anatomical targets. To overcome these limitations, we developed an invasive brain mapping paradigm in which electrodes were implanted across the OCD cortico-striato-thalamo-cortical circuit. We then performed extensive stimulation mapping during a multi-day inpatient stay to identify personalized therapeutic targets and characterize their downstream circuit effects. We found two targets within the right ventral capsule (VC) that acutely reduced OCD symptoms. Prolonged VC stimulation suppressed high frequency activity within the structurally and functionally connected orbitofrontal and cingulate cortex, which were identified to be cortical nodes encoding the severity of OCD symptoms. These VC sites were implanted for DBS and combined stimulation of these targets led to a rapid therapeutic response. This case provides the first proof-of-concept that invasive brain mapping can be used to guide a novel personalized, multi-site neuromodulation approach to treat refractory OCD.

Indexed as

Brain MappingDeep Brain StimulationGyrus CinguliObsessive-Compulsive DisorderElectrodes, ImplantedFemaleHumansMagnetic Resonance ImagingPrecision MedicinePrefrontal CortexYoung Adult

Identifiers

PMID41173862
PMCPMC12578982

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.