ArticleTranslational psychiatry2025
The application of amplitude of low-frequency fluctuations metrics in the diagnosis and prediction of treatment response as well as their associated genes and biological processes in patients with bipolar disorder.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimizing Treatment Strategies in the Bipolar Disorder Spectrum With Classical AI Approaches: Systematic Review of Performance, Bias, and Clinical Applicability.JMIR mental health · 2026Pooled it
- Revisiting Amplitude of Low-Frequency Fluctuations (ALFF) in Resting-State fMRI: Clarifications and Improvements.Human brain mapping · 2026Article
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Authors and funding
10 authors.
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Abstract
While previous studies have reported functional abnormalities in the prefrontal-limbic-subcortical circuit, the treatment effects on this activity remain unclear. This longitudinal study aimed to investigate spontaneous brain activity in bipolar disorder patients (BDPs) at baseline and after treatment. A total of 77 BDPs (with 38 completing the follow-up) and 83 healthy controls (HCs) were included in the final analysis. The amplitude of low-frequency fluctuations (ALFF), wavelet-ALFF, fractional ALFF (fALFF) metrics were used to assess regional spontaneous brain activity. Correlation analysis between functional changes and clinical characteristics was performed. Machine-learning approaches based on these three ALFF metrics were conducted for classification and prediction. We also performed a neuroimaging-transcription association analysis using Allen Human Brain Atlas. At baseline, all three ALFF metrics consistently revealed increased activity in the right caudate/putamen, whereas decreased ALFF and wavelet-ALFF values were observed in the left rectus/orbitofrontal gyrus (OFG) compared to HCs. Following 3 months of treatment, the baseline anomalies in the right caudate persisted while those in the OFG normalized towards the levels observed in HCs. There was an increased fALFF in the bilateral precuneus/calcarine gyrus compared to pre-treatment. The accuracy of classifiers based on ALFF, fALFF, and wavelet-ALFF were 75.6%, 74.4%, and 76.9%; correlation coefficients between predicted and actual treatment responses were 0.672, 0.722, and 0.662. Neuroimaging-transcription analysis identified genes and functional pathways correlated with spatial alterations. Taken together, dysfunction within the prefrontal-limbic-subcortical circuit might underlie neuropathological changes in BDPs. Medication appeared to have a normalizing effect on the functional abnormalities in BDPs.
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