Evidence map›Paper›PMID 41173171›Full record

ArticlePharmacological research2025

Targeting cellular senescence in dystrophin

Xueqin Gao, Joseph J Ruzbarsky, Matthieu Huard, S Amir H Sajedi, Peter T Shyu, Zuokui Xiao, Britney S Force, Sarah White, Jessica Ayers, Bing Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. CALLY index and bone mineral density as risk factors for adjacent vertebral fracture after balloon kyphoplasty for treatment of osteoporotic vertebral compression fracture: a retrospective analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xueqin GaoLinda and Mitch Hart Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States. Electronic address: xgao@sprivail.org.
Joseph J RuzbarskyLinda and Mitch Hart Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States; The Steadman Clinic, Aspen, CO, United States. Electronic address: jruzbarsky@thesteadmanclinic.com.
Matthieu HuardLinda and Mitch Hart Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States. Electronic address: mhuard@sprivail.org.
S Amir H SajediBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States. Electronic address: ss7233@columbia.edu.
Peter T ShyuBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States. Electronic address: pts2116@columbia.edu.
Zuokui XiaoLinda and Mitch Hart Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States. Electronic address: zxiao@sprivail.org.
Britney S ForceLinda and Mitch Hart Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States. Electronic address: bforce@sprivail.org.
Sarah WhiteLaboratory Animal Resources, Colorado State University, Fort Collins, CO, United States. Electronic address: Sarah.White2@colostate.edu.
Jessica AyersLaboratory Animal Resources, Colorado State University, Fort Collins, CO, United States. Electronic address: Jessica.Ayers@colostate.edu.
Bing WangDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: bingwang@pitt.edu.
X Edward GuoBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States. Electronic address: exg1@columbia.edu.
Johnny HuardLinda and Mitch Hart Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States. Electronic address: jhuard@sprivail.org.

Funding

Bone Abnormalities & Healing Defect in Muscular DystrophyR01AR065445 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HUARD, JOHNNY · 2014 to 2018
$1.7M
NIAMS NIH HHS R01 AR065445
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a severe genetic muscle disease caused by mutations of the dystrophin gene. Previous studies have detected senescent cells in the skeletal muscle of human DMD, dystrophin-deficient mice (Mdx), and rats. This study aimed to use a more severe dystrophin

Indexed as

Cellular SenescenceDystrophinLongevityMuscle, SkeletalMuscular Dystrophy, DuchennePyrazolesUtrophinAnimalsMacrophagesMaleMiceMice, Inbred C57BLMice, Inbred mdxMice, KnockoutNitrilesPyrimidinesDystrophinNitrilesPyrazolesPyrimidinesruxolitinibUtrophinBone healthCellular senescenceDeflazacortDystrophin(-/-)/Utrophin(-/-) miceMuscular dystrophyRuxolitinib

Identifiers

PMID41173171
PMCPMC12764366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.