Evidence map›Paper›PMID 41172988›Full record

ArticleImmunity2025

The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors.

Joseph Léger, Eva Artano, Delphine Coulais, Naomie Belletoise, Raoudha Fadhloun, Devin Kenney, Avinash Bhandoola, Christelle Harly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph LégerNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, 44007 Nantes, France.
Eva ArtanoNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, 44007 Nantes, France.
Delphine CoulaisNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, 44007 Nantes, France.
Naomie BelletoiseNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, 44007 Nantes, France.
Raoudha FadhlounNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, 44007 Nantes, France.
Devin KenneyLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Avinash BhandoolaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: avinash.bhandoola@nih.gov.
Christelle HarlyNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, 44007 Nantes, France; Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: christelle.harly@cnrs.fr.

Funding

T cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011633
6 · The paper itself

Abstract

Understanding the mechanisms that initiate innate lymphoid cell (ILC) specification may reveal how ILC functions in immunity and tissue homeostasis are programmed. Using an Il7r-lineage tracing mouse strain, we identified developmental intermediates between lymphoid progenitors and Tcf7

Indexed as

Basic-Leucine Zipper Transcription FactorsImmunity, InnateLymphocytesLymphoid Progenitor CellsAnimalsCell DifferentiationCell LineageCells, CulturedGATA3 Transcription FactorHepatocyte Nuclear Factor 1-alphaInhibitor of Differentiation Protein 2Killer Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutPromyelocytic Leukemia Zinc Finger ProteinBasic-Leucine Zipper Transcription FactorsGata3 protein, mouseGATA3 Transcription FactorHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseIdb2 protein, mouseInhibitor of Differentiation Protein 2Nfil3 protein, mousePromyelocytic Leukemia Zinc Finger ProteinZbtb16 protein, mousedevelopmentinnate lymphoid cellsNFIL3specificationToxtranscription factors

Identifiers

PMID41172988
PMCPMC13047858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.