ReviewSeminars in diagnostic pathology2025
GLI1-altered mesenchymal tumors of the head and neck.
Review in Seminars in diagnostic pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
GLI1-altered mesenchymal tumors are a group of soft tissue tumors that have emerged as a new entity, in large part, as a result of increased next-generation sequencing (NGS)-based DNA and RNA sequencing of tumors. Over the last decade, multiple case reports and small series have reported such tumors involving multiple sites (including soft tissue, head and neck and viscera). They appear to have rather distinctive morphology and can either show GLI1-gene fusions or GLI1-gene amplifications. Although cases with metastasis are increasingly recognized, definite morphologic indicators of metastasis have not yet been identified. In this review, we focus on GLI1-altered mesenchymal tumors of the head and neck, with an emphasis on clinicopathologic features, molecular findings and approach to the diagnosis.
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