Trial reportInternational dental journal2026
Effectiveness of Bioactive Glass-Based Toothpaste for Early Childhood Caries Prevention: A Randomized Controlled Trial.
Trial report in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Biomimetic Enamel Remineralization in Pediatric Dentistry: From Biological Principles to Clinical Evidence.Cureus · 2026Review
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Is bioactive glass toothpaste an effective alternative to fluoride toothpaste for preventing early childhood caries?Evidence-based dentistry · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimEarly childhood caries (ECC) remains a significant global health challenge. While fluoride-based treatments are the standard, bioactive glass (BAG) has emerged as a promising alternative for caries prevention. This clinical trial aimed to evaluate the effectiveness of a fluoride-free BAG-based toothpaste compared to a fluoride toothpaste in preventing ECC.
methodsThis double-blinded, multicentre, randomized controlled trial enrolled 1063 children aged 3 to 4 years from 12 kindergartens in Hubei, China. Participants were randomly assigned to either the test (fluoride-free toothpaste containing 7.5% (w/w) BAG) or the control (fluoride toothpaste containing 800 ppm F) group. The primary outcomes were caries increment, measured as changes in decayed, missing, and filled teeth (dmft) and surfaces (dmfs) scores, and caries incidence after 27 months. Secondary outcomes included caries increment and incidence assessed at 12 months of follow-up.
resultsBaseline characteristics were well balanced between the test and control groups. Both groups demonstrated progressive increases in caries measures during the follow-up periods, though no statistically significant differences emerged between the interventions. At 27 months, caries increment and incidence were comparable between the test and control groups (P > .05 for all comparisons). Similar patterns were observed at 12 months, with both groups showing equivalent caries progression. No adverse events were reported during the study period.
conclusionsThis trial revealed that fluoride-free toothpaste containing 7.5% (w/w) BAG exhibited comparable efficacy to 800 ppm fluoride toothpaste in preventing ECC over 27 months. However, both interventions were associated with substantial caries progression (mean dmft increment >2.0), indicating limited effectiveness in preschool children.
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