ArticleG3 (Bethesda, Md.)2026
The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization.
Article in G3 (Bethesda, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Review
- Article
- The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding 'ZZ' domain.bioRxiv : the preprint server for biology · 2025Article
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4 authors.
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Abstract
ORB2 is the Drosophila ortholog of the human CPEB2-4 family of RNA-binding proteins, which include a conserved C-terminal Zinc-binding ('ZZ') domain. We have recently shown that this domain interacts with several translational co-repressors in the early embryo, and that deletion of this domain from the endogenous orb2 gene results in derepression of its target mRNAs. Here we assess the effect of deletion of the ZZ domain on spermatogenesis. We find that deletion of the ZZ domain does not affect spatial localization of the ORB2 protein; orb2ΔZZ flies are sterile and lack mature sperm; meiosis is mostly normal in orb2ΔZZ testes; individualization complexes are defective and spermatid individualization fails; proteins known to play a role in spermatid individualization-ORB, IMP, SOTI-are mislocalized; and the SOTI-dependent Cleaved Caspase-3 gradient no longer forms in orb2ΔZZ mutant testes.
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