Evidence map›Paper›PMID 41171930›Full record

ArticleScience advances2025

T

Samuel J Connell, Sydney Crotts, Ryan Reis, Maddison M Lensing, Payton Kahl, Nicholas Henderson, Otgonzaya Ayush, Zhaowen Zhu, Luana S Ortolan, Audrey C Ko and 5 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Samuel J ConnellInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-2713-7210
Sydney CrottsDepartment of Dermatology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-2962-3848
Ryan ReisDepartment of Dermatology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-9831-757X
Maddison M LensingInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-4321-5517
Payton KahlDepartment of Dermatology, University of Iowa, Iowa City, IA, USA.ORCID 0009-0008-5050-5492
Nicholas HendersonDepartment of Dermatology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-3701-5612
Otgonzaya AyushDepartment of Dermatology, University of Iowa, Iowa City, IA, USA.
Zhaowen ZhuDepartment of Dermatology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-5887-2678
Luana S OrtolanDepartment of Dermatology, University of Iowa, Iowa City, IA, USA.
Audrey C KoDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-5915-1645
Erin M ShriverDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
Keith D CarterDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-2300-5747
John T HartyInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-7266-2802
Joan M GovermanDepartment of Immunology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7361-9424
Ali JabbariInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-8559-7314

Funding

PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
IL-27 and downstream mechanisms in Alopecia AreataR01AR077194 · NIAMS · UNIVERSITY OF IOWA · PI JABBARI, ALI · 2021 to 2025
$1.7M
Defining T helper cell associated cytokines and mechanisms in Alopecia AreataK08AR069111 · NIAMS · UNIVERSITY OF IOWA · PI JABBARI, ALI · 2016 to 2020
$854k
Full Spectrum Cell Sorter Flow CytometerS10OD034193 · OD · UNIVERSITY OF IOWA · PI BALLAS, ZUHAIR K. · 2023 to 2023
$526k
BLRD VA I01 BX004907NIAID NIH HHS T32 AI007485NIAMS NIH HHS K08 AR069111NIAMS NIH HHS R01 AR077194NIH HHS S10 OD034193
6 · The paper itself

Abstract

Alopecia areata (AA) is an autoimmune disease defined by hair loss and peribulbar infiltrate of CD8 and CD4 T cells. Prior studies have focused on the role of CD8 T cells in the development of AA. Multiple roles for CD4 T cell help have been demonstrated for support of CD8 T cell responses; however, the role of CD4 T cells in AA remains unclear. Here, we demonstrate that CD4 T cells from the skin-draining lymph nodes (SDLNs) of AA mice transferred disease to recipient mice. These cells exhibited a T helper type 1 (T

Indexed as

Alopecia AreataCD4-Positive T-LymphocytesInterferon-gammaTh1 CellsAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalHumansLymph NodesMiceMice, Inbred C57BLInterferon-gamma

Identifiers

PMID41171930
PMCPMC12577704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.