ArticlePloS one2025
Pan-immune inflammation value: A novel biomarker for cataract.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association between inflammatory biomarkers and cataracts: validation from the NHANES database and clinical studies.Frontiers in nutrition · 2026Article
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Authors and funding
7 authors.
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Abstract
backgroundInflammation significantly contributes to cataract formation; Pan-immune inflammation value (PIV) is an emerging marker that may reflect systemic inflammation. This study aimed to explore the connection between PIV and cataract formation.
methodsWe analyzed 8,235 participants from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2008. PIV was log-transformed, and weighted logistic regression, restricted cubic splines (RCS), subgroup, and sensitivity analyses were performed to evaluate associations. The receiver operating characteristic (ROC) curves were used to assess predictive performance.
resultsCataract prevalence was 6.6%. Higher ln-PIV was positively associated with cataract prevalence [OR=1.35, 95%CI: 1.08-1.69, P = 0.015]. The association was linear, consistent across subgroups, and robust in sensitivity analyses. The ROC analysis indicated that PIV had better predictive ability for cataract than other inflammatory indices.
conclusionWe found that higher PIV levels were positively associated with cataract prevalence, which highlights the value of inflammatory markers in assessing cataract development and provides new ideas for the clinical detection of cataracts.
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