ArticlePloS one2025
Micro-Computed Tomography as a complementary tool for histopathological diagnosis of oral soft tissue lesions - Proof of concept.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Beyond the surface: A review of current and potential micro-CT applications in paleopathology.International journal of paleopathology · 2026Review
- A laboratory micro-CT technique is useful to visualize and characterize dermal skin components in a 3D manner.Experimental and therapeutic medicine · 2026Article
- A novel non-invasive imaging technique for mapping microplastic accumulation and distribution in different organ systems of Indian major carpCurrent research in toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate diagnosis of oral soft tissue lesions is critical for effective treatment, yet conventional histopathological examination, the gold standard, faces limitations. These include two-dimensional (2D) visualization and malorientation, which can obscure critical diagnostic features, like epithelial-connective tissue interfaces. Micro-computed tomography (µCT) offers a non-destructive, high-resolution three-dimensional (3D) imaging alternative to address these challenges. Still, its use for soft tissue visualization is limited. We tested a method with specific radio-opaque staining and µCT scanning settings to visualize oral soft tissue biopsies as a proof of concept.
methodsBiopsies from 12 patients with different oral mucosa lesions were stained with Lugol's iodine, scanned at 3µm resolution with 70kV energy, and the resulting volumes were compared to histopathological sections by specialists in oral radiology and oral pathology.
resultsµCT produced 2D images with tissue architecture comparable to hematoxylin and eosin (H&E)-stained sections, distinguishing epithelium, connective tissue, and keratin, while 3D reconstructions revealed topographic details, such as ulceration depth and vascular patterns, unattainable in histopathology.
conclusionsThese findings highlight µCT potential as a complementary diagnostic tool, enhancing topographic rendering while preserving tissue integrity. Standardized protocols and broader validation, particularly for precancerous and malignant lesions, are essential for clinical adoption, promising improved diagnostic accuracy in oral pathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.