ArticleTransplantation2026
Early Postreperfusion Proteomics Reveal Divergent Inflammatory Responses in Kidney Transplantation With Implications on Outcomes.
Article in Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nuclear cell-free DNA on the loose: an early warning signal of ischemia-reperfusion injury in kidney transplantation.Frontiers in immunology · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemia/reperfusion injury is an unavoidable consequence of kidney transplantation, yet the characteristics of the immediate immune response after reperfusion and its impact on transplant outcomes remain poorly characterized in the clinical setting.
methodsWe conducted a cohort study including 63 kidney transplant recipients (26 living-donor, 37 deceased-donor) with an extended 4-y follow-up to characterize early postreperfusion inflammatory dynamics and their association with transplant outcomes. Using high-throughput proteomics, we profiled 92 inflammatory markers in the early reperfusion stage. Intraoperative blood samples were collected systemically at baseline and from the transplant vein at 1, 10, and 30 min postreperfusion.
resultsOur analysis revealed a pronounced early immune response on reperfusion, with distinct inflammatory trajectories between living- and deceased-donor kidney allografts. Living-donor allografts showed proteomic patterns suggestive of a regulatory response, whereas deceased-donor allografts exhibited patterns associated with a cell injury-related response. Notably, interleukin-33 and hepatocyte growth factor were associated with delayed graft function, whereas hepatocyte growth factor also correlated with long-term allograft dysfunction.
conclusionsThese findings underscore the potential of assessing early postreperfusion inflammation to improve clinical risk stratification and guide future biomarker validation efforts.
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