ArticleDiscover oncology2025
The causal association between psychiatric disorders and gynecological cancer: a bidirectional Mendelian randomization study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundPrevious studies have suggested a positive causal relationship between schizophrenia and ovarian, breast, and lung cancers. Additionally, research has indicated a positive correlation between bipolar disorder and thyroid cancer. However, some studies have also shown that mental disorders do not increase the risk of cancer, however, the causal relationship has yet to be thoroughly explored. In this study, we employed Mendelian randomization (MR) to examine the genetic connections between mental disorders and the risk of gynecological cancers.
methodsWe analyzed data from genome-wide association studies (GWAS) on five mental disorders [schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD)] and three gynecological cancers [cervical cancer (CC), ovarian cancer (OC), and endometrial cancer (EC)]. Instrumental variables were identified using significant single nucleotide polymorphisms (SNPs). We applied inverse variance weighting (IVW), weighted median (WM), and MR-Egger regression methods to assess the results, reporting effect sizes as odds ratios (OR) with 95% confidence intervals (CI).
resultsGenetically predicted MDD was found to be causally associated with an increased risk of LGSOC (OR = 1.50; 95% CI: 1.07–2.09; P = 0.01), MOC (OR = 1.46; 95% CI: 1.0–1.94; P = 0.008), BD with a decreased risk of EEC (OR = 0.76, 95% CI: 0.60–0.97, P = 0 .0249), and ADHD with an increased risk of LGSOC (OR = 1.48, 95% CI: 1.04–2.1, P = 0.0293).
conclusionsOur study provides evidence of a causal relationship between genetically predicted MDD and OC risk, as well as between ADHD and OC risk. Additionally, we found that BD is linked to a reduced risk of EC.
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