Evidence map›Paper›PMID 41171464›Full record

ArticleBiogerontology2025

Age-related decline in protein turnover highlights cystatin C dysfunction and links proteostasis collapse to neuroinflammation in the murine cortex.

Daiana Burdusel, Sina Ghaemmaghami, Diana-Larisa Ancuta, Coman Cristin, Dirk Hermann, Thorsten Doeppner, Denisa F V Pirscoveanu, Aurel Popa-Wagner

Abstract read
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In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daiana Burdusel *Doctoral School, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania.
Sina Ghaemmaghami *Department of Biology, University of Rochester, 326 Hutchison Hall, Rochester, NY, 14627, USA.
Diana-Larisa AncutaDepartment of Research and Development, Cantacuzino National Medical Military Institute, 050096, Bucharest, Romania.
Coman CristinDepartment of Research and Development, Cantacuzino National Medical Military Institute, 050096, Bucharest, Romania.
Dirk HermannDoctoral School, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania.
Thorsten DoeppnerDoctoral School, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania.
Denisa F V PirscoveanuDoctoral School, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania. pirscoveanudenisa@gmail.com.
Aurel Popa-WagnerDoctoral School, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania.

Funding

"The National Recovery and Resilience Plan" set up by the European Union, PNRR 760058
6 · The paper itself

Abstract

One of the key hallmarks of aging is the breakdown of proteostasis-the finely tuned balance of protein synthesis, folding, trafficking, and degradation that maintains proteome integrity and cellular function. In this study, we employed

Indexed as

AgingCerebral CortexCystatin CNeuroinflammatory DiseasesProteostasisAnimalsMaleMiceMice, Inbred C57BLCystatin CAgeingBrainCystatin CIsotopic labellingNeurodegenerationNeuroinflammationProteostasis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.