Evidence map›Paper›PMID 41171426›Full record

ArticleArchives of toxicology2026

Cutaneous effects of ovatoxin-a: an in vitro study on human skin keratinocytes.

Alessandra D'Arelli, Michela Carlin, Silvio Sosa, Chiara Melchiorre, Fabio Varriale, Luciana Tartaglione, Michela Varra, David Kulis, Donald M Anderson, Mark Poli and 3 more

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In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alessandra D'ArelliDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Michela CarlinDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Silvio SosaDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Chiara MelchiorreSchool of Medicine and Surgery, Department of Pharmacy, University of Naples Federico II, Naples, Italy.
Fabio VarrialeSchool of Medicine and Surgery, Department of Pharmacy, University of Naples Federico II, Naples, Italy.
Luciana TartaglioneSchool of Medicine and Surgery, Department of Pharmacy, University of Naples Federico II, Naples, Italy.
Michela VarraSchool of Medicine and Surgery, Department of Pharmacy, University of Naples Federico II, Naples, Italy.
David KulisWHOI, Woods Hole Oceanographic Institution, Woods Hole, MA, 02543, USA.
Donald M AndersonWHOI, Woods Hole Oceanographic Institution, Woods Hole, MA, 02543, USA.
Mark PoliDiagnostic Systems Division, USAMRIID, U.S. Army Medical Research Institute of Infectious Diseases, Ft Detrick, MD, USA.
Aurelia TubaroDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Carmela Dell'AversanoSchool of Medicine and Surgery, Department of Pharmacy, University of Naples Federico II, Naples, Italy.
Marco PelinDepartment of Life Sciences, University of Trieste, Trieste, Italy. mpelin@units.it.ORCID 0000-0002-4306-7411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovatoxin-a (OVTX-a) is the main palytoxin (PLTX) analogue produced by the marine benthic dinoflagellate Ostreopsis cf. ovata from the Mediterranean area, where it poses risks for human health mainly through inhalation of marine aerosols and/or skin contact with contaminated seawater. Herein, we highlight the effects of OVTX-a, in comparison to PLTX, at the skin level using human HaCaT keratinocytes, employing a sample containing OVTX-a at 86% purity. After 4 h exposure, OVTX-a reduced cell viability (EC

Indexed as

AcrylamidesKeratinocytesMarine ToxinsSkinCell LineCell SurvivalCnidarian VenomsDinoflagellidaHaCaT CellsHumansMembrane Potential, MitochondrialOxidative StressPolyether ToxinsReactive Oxygen SpeciesAcrylamidesCnidarian VenomsMarine ToxinspalytoxinPolyether ToxinsReactive Oxygen SpeciesCutaneous toxicityMechanism of actionOstreopsis cf. ovataOvatoxin-aPalytoxin

Identifiers

PMID41171426
PMCPMC12886334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.