Evidence map›Paper›PMID 41171408›Full record

ArticleAbdominal radiology (New York)2026

Prognostic imaging features of ovarian clear cell carcinoma on multiparametric MRI.

Tetsuya Abe, Tsukasa Saida, Miki Yoshida, Kaoru Fujieda, Sodai Hoshiai, Toshitaka Ishiguro, Taishi Amano, Ayumi Shikama, Toyomi Satoh, Takahito Nakajima

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Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tetsuya AbeDepartment of Diagnostic and Interventional Radiology, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, 305-8576, Japan.
Tsukasa SaidaDepartment of Radiology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. saida_sasaki_tsukasa@md.tsukuba.ac.jp.
Miki YoshidaDepartment of Diagnostic and Interventional Radiology, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, 305-8576, Japan.
Kaoru FujiedaObstertrics and Gynecology, Univercity of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, 305-8575, Japan.
Sodai HoshiaiDepartment of Radiology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Toshitaka IshiguroDepartment of Radiology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Taishi AmanoDepartment of Radiology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Ayumi ShikamaDepartment of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennoda, Tsukuba, Ibaraki, 305-8575, Japan.
Toyomi SatohDepartment of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennoda, Tsukuba, Ibaraki, 305-8575, Japan.
Takahito NakajimaDepartment of Radiology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare preoperative MRI features between ovarian clear cell carcinoma (CCC) patients with favorable versus unfavorable clinical outcomes and to identify imaging predictors associated with adverse outcomes.

methodsWe retrospectively analyzed patients with pathologically confirmed CCC to compare preoperative MRI and clinical features between the recurrence-free and unfavorable-outcome groups. Quantitative variables included MRI parameters such as tumor size, T1 ratio of the cystic component, and for the solid component, maximum width and height, T2 ratio, apparent diffusion coefficient (ADC), and dynamic contrast-enhanced (DCE) metrics, as well as clinical/laboratory data (age and serum tumor marker levels). Qualitative variables included MRI findings such as number of locules, number of solid components (≤ 3 vs. ≥4 solid components or diffuse mural thickening), presence of marked T2 hyperintensity, growth pattern, presence of necrosis, and time-intensity curve (TIC) pattern, as well as FIGO stage, and surgical completeness.

resultsSeventy-two patients were included (recurrence-free, n = 45; unfavorable-outcome, n = 27). The distribution of FIGO stage differed between the groups (p < 0.001), and complete surgery was achieved significantly less often in the unfavorable-outcome group (77.8%, p = 0.002). Among the MRI parameters, only ≥ 4 solid components were significantly associated with unfavorable outcomes (p = 0.020). In stage I-II cases, the same trend was observed, although not significant (p = 0.147). No significant associations were observed for any other variables, including tumor size, T1 ratio of the cystic component, maximum width and height of the solid component, growth pattern, T2 ratio, ADC, DCE metrics, TIC pattern, or clinical and laboratory data (p = 0.050-1.000).

conclusionIn this cohort of CCC patients, multiparametric MRI showed that the presence of four or more solid components, together with FIGO stage and surgical completeness, was associated with unfavorable clinical outcomes, suggesting a potential role for MRI-based risk stratification that warrants external validation.

Indexed as

Adenocarcinoma, Clear CellMagnetic Resonance ImagingMultiparametric Magnetic Resonance ImagingOvarian NeoplasmsAdultAgedContrast MediaFemaleHumansMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesContrast MediaCancerMagnetic resonance imagingOvaryPrognosisRisk stratification

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.