Interventional effects of targeted anti-infective therapy on disease severity and inflammatory cytokine levels in critically Ill patients with urinary sepsis in tertiary hospitals in Chongqing, China.

This work aimed to demonstrate the effects of targeted antibacterial therapy on the condition and levels of inflammatory markers in critically ill patients with urosepsis. The study subjects were recruited from the Department of Urology at Dianjiang County People's Hospital (Grade A Tertiary General Hospital) in Chongqing, China. Between January 2019 and January 2021, 86 critically ill patients with urosepsis were recruited and they were assigned to targeted group (FG, n = 43) and routine group (RG, n = 43). The FG patients had urine samples collected for laboratory culturing, and antibacterial were administered based on bacterial culture and sensitivity results. The RG patients received conventional antibacterial therapy. On days 1 and 3, neglectable differences were observed in the levels of lactic acid (Lac), creatinine (Cr), bilirubin (Bil), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), scute physiology and chronic health evaluation II (APACHE II), and sequential organ failure assessment (SOFA) scores (P > 0.05). Nevertheless, on days 7 and 14, there were drastic differences in Lac, Cr, Bil, TNF-α, IL-6, CRP levels, and APACHE II and SOFA scores (P < 0.05). Targeted antibacterial therapy proves to be an effective intervention method for critically ill patients with urosepsis, as it not only lowers the levels of inflammatory markers but also reduces the incidence of complications.