ArticleClinical and experimental medicine2025
A closer look to the lung involvement in ANCA-associated vasculitis: alveolar haemorrhage and interstitial lung disease.
Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Review
- Prevalence and clinical outcomes of fibrotic interstitial lung disease in ANCA associated vasculitis: a single-centre, retrospective, cohort study.Respiratory research · 2026Article
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3 authors.
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Abstract
Interstitial lung disease (ILD) and alveolar haemorrhage (AH) have been described as possible pulmonary involvements associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), mainly granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). To evaluate the clinical, laboratory and demographic features of ANCA positivity in AAV; in particular, we aimed to determine the criteria predicting ILD involvement and AH. This study was designed as a cross-sectional and retrospective study conducted in a single centre. The studies comprised 83 individuals in total who were routinely followed at a tertiary rheumatology clinic between June 2016 and February 2024. A total of 83 patients consisting of 56 GPA (67.4%), 22 MPA (26.5%) and 5 ANCA-negative (6.1%) cases were included in the study. When adjusted for age and sex in a multivariate regression model, the correlation of AH with C-ANCA was confirmed (OR 4.80; 95% CI 1.29-17.91) (p = 0.020). The subsequent multivariate regression analysis reveals that the P-ANCA variable significantly predicts ILD (OR 4.28; 95% CI 1.25-14.65) (p = 0.021) when adjusted for age and sex. AH was found to be higher in patients with GPA and in patients with C-ANCA positivity. It was shown that P-ANCA positivity predicted ILD involvement in AAV patients. The widespread ILD involvement observed in P-ANCA-positive patients confirmed usual interstitial pneumonia, but nonspecific interstitial pneumonia was also found to predominate in C-ANCA-positive and ANCA-negative cases.
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