Evidence map›Paper›PMID 41171329›Full record

ArticleBulletin of experimental biology and medicine2025

Psychopharmacological and Neuroregenerative Properties of Protein Kinase A Inhibitor in Alzheimer's Disease Model.

G N Zyuz'kov, V V Zhdanov, L A Miroshnichenko, T Yu Polyakova, A V Chaykovskyi, V I Agafonov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

G N Zyuz'kovLaboratory of Pathophysiology and Experimental Therapy, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. zgn@pharmso.ru.
V V ZhdanovLaboratory of Pathophysiology and Experimental Therapy, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
L A MiroshnichenkoLaboratory of Pathophysiology and Experimental Therapy, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
T Yu PolyakovaLaboratory of Pathophysiology and Experimental Therapy, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A V ChaykovskyiLaboratory of Pathophysiology and Experimental Therapy, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
V I AgafonovLaboratory of Pathophysiology and Experimental Therapy, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effect of a protein kinase A (PKA) inhibitor and the content of different types of progenitor cells in the subventricular zone of the brain of 16-month-old male C57BL/6 mice (characterized by pathological endogenous amyloid formation in the brain) and on the mental status of these mice. The pharmacological agent ameliorated disorders of orientation and exploratory behavior and conditioned response performance in experimental animals. At the same time, an increase in the content of resident neural stem cells and committed neuronal precursors in the nervous tissue was found.

Indexed as

Alzheimer DiseaseCyclic AMP-Dependent Protein KinasesProtein Kinase InhibitorsAnimalsBrainDisease Models, AnimalExploratory BehaviorMaleMiceMice, Inbred C57BLNeural Stem CellsCyclic AMP-Dependent Protein KinasesProtein Kinase InhibitorsAlzheimer’s diseaseintracellular signal transductionneural stem cellsneuroregenerationprotein kinase A (PKA) inhibitors

Identifiers

PMID41171329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.