Evidence map›Paper›PMID 41171328›Full record

ArticleBulletin of experimental biology and medicine2025

Anticonvulsant Activity of 12-Epinapelline N-Oxide, a Diterpene Alkaloid of the Atisine Series.

Yu V Nesterova, O V Vsyakikh, T N Povetyeva, N I Suslov, P V Kulpin, O G Afanas'eva, G N Zyuz'kov, V V Zhdanov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu V NesterovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. nes-yuliya@yandex.ru.
O V VsyakikhGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
T N PovetyevaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
N I SuslovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
P V KulpinGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
O G Afanas'evaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
G N Zyuz'kovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
V V ZhdanovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anticonvulsant activity of the diterpene alkaloid 12-epinapelline N-oxide isolated from the aboveground part of Aconitum baicalense was demonstrated in experiments on mice with modeled maximal electroshock-induced seizure and pentylenetetrazol-induced seizures. Taking into account the mechanism of seizure development in the studied models, we can hypothesize that the anticonvulsive activity of the alkaloid is determined by its interaction with Na

Indexed as

AlkaloidsAnticonvulsantsDiterpenesSeizuresAconitumAnimalsElectroshockMaleMicePentylenetetrazoleReceptors, GABA-ASodium ChannelsAlkaloidsAnticonvulsantsDiterpenesPentylenetetrazoleReceptors, GABA-ASodium Channelsditerpene alkaloids; 12epinapelline Ninduced seizure; pentylenetetrazoleinduced seizure testoxide; anticonvulsive activity; maximal electroshock

Identifiers

PMID41171328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.