Effect of Dihydrexidine Hydrochloride on Early Consolidation and Retrieval of Long-Term Memory in Rats with Different Spatial Learning Abilities.

A T Proshin, E I Zakharova, A M Dudchenko, S S Pertsov

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A T ProshinFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia. proshin_at@academpharm.ru.

E I ZakharovaInstitute of General Pathology and Pathophysiology, Moscow, Russia.

A M DudchenkoInstitute of General Pathology and Pathophysiology, Moscow, Russia.

S S PertsovFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the participation of the brain dopaminergic system in cognitive processes in rats on the model of spatial learning in the Morris water maze. Administration of the dopamine D1/5-receptor agonist dihydrexidine hydrochloride during repeated training in the Morris water maze resulted in improvement of early memory consolidation by the platform search time index selectively in animals with low abilities to perform the task at this stage of training, but not in individuals with high abilities to early memory consolidation. The agonist was also ineffective in rats with low memory consolidation abilities at all stages of memory formation. In the retrieval phase after repeated training, the agonist improved the retrieval of the skill in rats with low abilities to perform the task. The results illustrate the involvement of the brain dopaminergic system in rats not only in the processes of early spatial memory consolidation, but also in the retrieval of the memory trace after learning.

Indexed as

Dopamine AgonistsMemory ConsolidationMemory, Long-TermSpatial LearningAnimalsMaleMaze LearningMorris Water Maze TestRatsRats, WistarReceptors, Dopamine D1Dopamine AgonistsReceptors, Dopamine D1cognitive abilities of ratsconsolidation and retrieval of long-term memoryD1/5 receptorsdihydrexidine hydrochlorideMorris water maze

Identifiers

PMID41171323

DOI10.1016/j.neuropharm.2007.02.010

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.