Evidence map›Paper›PMID 41171322›Full record

ArticleBulletin of experimental biology and medicine2025

Adrenomedullin in Blood Plasma in Normotensive and Spontaneous Hypertensive Rats: Effect of Increased Blood Viscosity.

A V Sidekhmenova, A M Anishchenko, O I Aliev, O A Ulyakhina, O I Poleshchuk, A A Ligacheva, M B Plotnikov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

A V SidekhmenovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. sidehmenova@yandex.ru.
A M AnishchenkoGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
O I AlievGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
O A UlyakhinaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
O I PoleshchukGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A A LigachevaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
M B PlotnikovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We measured the plasma levels of adrenomedullin in normotensive Wistar rats and spontaneously hypertensive rats (SHR) was investigated, and evaluated changes in its level under conditions of increased blood viscosity. Blood viscosity was increased by the method of isovolumic hemoconcentration (replacement of 10% of circulating blood with the same volume of packed erythrocytes of donor rats). The initial concentration of adrenomedullin in Wistar rats was 1912 ± 195 pg/ml, while in SHR it was 40% lower (p = 0.007). In Wistar rats, an increase in blood viscosity was accompanied by a decrease in the concentration of adrenomedullin by 1.8 times in comparison with the initial value, while in SHR it did not lead to significant changes in adrenomedullin level. The absence of changes in the plasma adrenomedullin concentration in SHR in response to blood viscosity elevation may indicate that the mechanotransduction mechanism is excluded from the regulation of vascular tone, which is probably one of the forms of endothelial dysfunction associated with its impaired sensitivity to shear stress changes.

Indexed as

AdrenomedullinBlood ViscosityHypertensionAnimalsBlood PressureMaleRatsRats, Inbred SHRRats, WistarAdrenomedullinadrenomedullinarterial hypertensionendothelial shear stressnormotensive Wistar ratsspontaneously hypertensive SHR rats

Identifiers

PMID41171322

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.