Evidence map›Paper›PMID 41171192›Full record

ArticleJournal of virology2025

Engineering a TGEV S-trimer chimera with PEDV D0-NTD generates potent neutralizing antibodies against both viruses.

Ding Zhang, Yang Yuan, Guangli Hu, Yunfei Xie, Xiumei Meng, ZhaoTian Zhang, Yu Zhang, Qi Liao, Ashenafi Assefa Gebremariam, Hanqin Shen and 2 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ding Zhang *State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-5520-7629
Yang Yuan *State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Guangli Hu *State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Yunfei XieState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Xiumei MengState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
ZhaoTian ZhangState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Yu ZhangState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Qi LiaoState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Ashenafi Assefa GebremariamState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Hanqin ShenGuangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control, Wen's Foodstuff Group Co. Ltd, Yunfu, China.ORCID 0000-0001-7556-2268
Guiqing PengState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-8813-6663
Yuejun ShiState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-9500-6995

Funding

National Science Fund for Distinguished Young Scholars 32125037
6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV), two economically devastating swine enteric coronaviruses, persistently threaten global pork production via severe clinical morbidity. Vaccination is the most effective means to prevent morbidity and mortality caused by porcine enteric coronavirus infection. Hence, the development of an effective and safe vaccination strategy to protect against both PEDV and TGEV infections is urgently needed. Here, we designed and produced trimerized full-length PEDV and TGEV spike (S) proteins using an efficient mammalian expression vector system in HEK293F cells and reported that compared with the PEDV spike protein (2

Indexed as

Antibodies, NeutralizingAntibodies, ViralGastroenteritis, Transmissible, of SwinePorcine epidemic diarrhea virusSpike Glycoprotein, CoronavirusTransmissible gastroenteritis virusAnimalsCoronavirus InfectionsHEK293 CellsHumansMiceMice, Inbred BALB CRecombinant Fusion ProteinsSwineViral VaccinesAntibodies, NeutralizingAntibodies, ViralRecombinant Fusion ProteinsSpike Glycoprotein, CoronavirusViral Vaccineschimeric spike proteincross-protectionimmunogenicityporcine epidemic diarrhea virus (PEDV)subunit vaccinetransmissible gastroenteritis virus (TGEV)

Identifiers

PMID41171192
PMCPMC12645917

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.