Evidence map›Paper›PMID 41171164›Full record

ArticleMolecular pharmaceutics2025

Structure-Based Modeling of Environment-Dependent Protonation States Across LNP Formulations with Atomistic CpHMD.

Kyle J Colston, Santiago C Monsalve, Severin T Schneebeli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Decoding pH-Driven Phase Transition of Lipid Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kyle J ColstonDepartment of Industrial and Molecular Pharmaceutics, Purdue University, West Lafayette, Indiana 47907, United States.
Santiago C MonsalveDepartment of Industrial and Molecular Pharmaceutics, Purdue University, West Lafayette, Indiana 47907, United States.
Severin T SchneebeliDepartment of Industrial and Molecular Pharmaceutics, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-9511-9922

Funding

Robust Sequence-defined Nanocages with Protein-mimetic CavitiesR35GM147579 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Severin Thomas Schneebeli · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM147579
6 · The paper itself

Abstract

The p

Indexed as

LipidsNanoparticlesHydrogen-Ion ConcentrationLiposomesMolecular Dynamics SimulationProtonsLipid NanoparticlesLipidsLiposomesProtonsAll-Atom ModelingConstant pH Molecular DynamicsEnvironment Dependent pKaLipid Nanoparticle FormulationsmRNA Delivery

Identifiers

PMID41171164
PMCPMC13245275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.