Evidence map›Paper›PMID 41171107›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Nherf2 is a major determinant of bile acid pool dynamics and contributes to regulation of Western diet-induced obesity.

Dachuan Dong, Wen-Jun Shen, Stefanie Bittner, Jia Chen, Xiao Hao, Mark Donowitz, Fredric B Kraemer, Salman Azhar

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dachuan DongGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, United States.ORCID 0000-0002-5443-5304
Wen-Jun ShenGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, United States.ORCID 0000-0001-5150-1698
Stefanie BittnerGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, United States.
Jia ChenDepartment of Medicine, Stanford University, Stanford, California, United States.
Xiao HaoDepartment of Medicine, Stanford University, Stanford, California, United States.
Mark DonowitzDepartment of Medicine, Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0003-0477-8824
Fredric B KraemerGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, United States.ORCID 0000-0003-2468-7807
Salman AzharGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, United States.ORCID 0009-0007-6755-1180

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
BLRD VA I01 BX000398BLRD VA I01 BX001923BLRD VA IK6 BX004200HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30DK116074NIDDK NIH HHS P30 DK116074U.S. Department of Veterans Affairs (VA) I01BX000398U.S. Department of Veterans Affairs (VA) I01BX001923U.S. Department of Veterans Affairs (VA) IK6B004200
6 · The paper itself

Abstract

Dysregulation of cholesterol metabolism can lead to obesity and increase the risk of developing many diseases, including type 2 diabetes and cardiovascular diseases. Our previous studies have identified postsynaptic density-95, disc large, and zonula occludens-1 (PDZ) adaptor proteins Na

Indexed as

Bile Acids and SaltsDiet, WesternObesityPhosphoproteinsSodium-Hydrogen ExchangersAnimalsCholesterolFemaleLiverMaleMiceMice, Inbred C57BLMice, KnockoutBile Acids and SaltsCholesterolPhosphoproteinssodium-hydrogen exchanger regulatory factorSodium-Hydrogen Exchangersbile acidcholesterolNherf2obesityPDZ

Identifiers

PMID41171107
PMCPMC12716856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.