Evidence map›Paper›PMID 41171098›Full record

ArticleHistopathology2026

Correlation of unfavourable and favourable histology at radical prostatectomy with Decipher scores and freedom from biochemical recurrence.

Nancy Y Greenland, Janet E Cowan, Chien-Kuang Cornelia Ding, Deepika Sirohi, Matthew R Cooperberg, Peter R Carroll, Jeffry P Simko, Bradley A Stohr, Li Zhang, Emily Chan

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In one paragraph

Article in Histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Nancy Y GreenlandDepartment of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-1783-1711
Janet E CowanDepartment of Urology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Chien-Kuang Cornelia DingDepartment of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-9047-0222
Deepika SirohiDepartment of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-0848-4172
Matthew R CooperbergUCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
Peter R CarrollUCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
Jeffry P SimkoDepartment of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Bradley A StohrDepartment of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-5836-2624
Li ZhangDepartment of Epidemiology and Biostatistics, University of California San Francisco (UCSF), San Francisco, CA, USA.
Emily ChanDepartment of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-7290-4004

Funding

The University of California San Francisco (UCSF) Urologic Outcomes Database has received funding from the Goldberg-Benioff Fund for Translational Cancer Biology.
6 · The paper itself

Abstract

introductionA recent study proposed a system of unfavourable and favourable histology categories to risk-stratify prostate cancer patients. We hypothesized that unfavourable histology would be associated with higher Decipher radical prostatectomy (RP) scores and would improve biochemical recurrence (BCR) prediction. MATERIALS AND

methodsThe RP slide with Decipher testing was classified as having either unfavourable or favourable histology, with unfavourable histology defined as the presence of Gleason pattern 5, large cribriform (diameter >0.25 mm), intraductal carcinoma, complex intraluminal papillary architecture, anastomosing cords of epithelium with or without cribriform spaces and/or grade 3 stromogenic carcinoma. Favourable histology was defined as the absence of unfavourable histology patterns. The association between favourable/unfavourable histology and Decipher RP score was evaluated using the Mann-Whitney test. Univariable and multivariable analyses to test for a statistically significant association between the predictors favourable/unfavourable histology, age, PSA at diagnosis, race, RP grade group, pT and pN stage and margin status and the risk of BCR were performed.

resultsFour hundred and eleven RP cases from 2014 to 2020 were classified as 306 (74.5%) unfavourable and 105 (25.5%) favourable. Median Decipher scores were 0.7 for unfavourable and 0.52 for favourable (P < 0.001), corresponding to Decipher assay high and intermediate risk categories, respectively. On univariate analysis, unfavourable histology compared to favourable histology was significantly associated with decreased time to BCR, which remained significant in a multivariable model (HR 1.65; 95% CI 1.04-2.64, P = 0.035).

conclusionsUnfavourable histology was associated with higher Decipher scores and increased BCR risk. The addition of the histology category improved BCR prediction in a multivariable model.

Indexed as

Neoplasm Recurrence, LocalProstatic NeoplasmsAgedHumansMaleMiddle AgedNeoplasm GradingProstatectomyProstate-Specific AntigenRisk AssessmentProstate-Specific AntigenDecipherfavourable histologylarge cribriformprostate cancerunfavourable histology

Identifiers

PMID41171098
PMCPMC12793803

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.