ArticleFuture oncology (London, England)2025
Personalized risk prediction of lateral lymph node metastasis in male papillary thyroid cancer: a sex-specific model leveraging central lymph node ratio.
Article in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsNotable sex-based disparities exist in papillary thyroid carcinoma (PTC), necessitating male-specific models for predicting lateral lymph node metastasis (LLNM) to guide treatment.
methodsWe developed and validated two nomograms, based on central lymph node ratio (LNR) and preoperative ultrasound (US), respectively, using data from 433 male PTC patients who underwent total thyroidectomy (TT) with central and lateral neck lymph node dissection. Multivariable analysis identified key risk factors. Model performance was evaluated using ROC curves, calibration curves, and decision curve analysis (DCA) across training and validation sets.
resultsMale patients had 1.33-fold higher odds of central lymph node metastasis (CLNM) and 1.51-fold higher odds of LLNM than female patients (
conclusionsThe nomogram based on the central LNR provides a precise and clinically valuable tool for the individualized prediction of LLNM in male PTC patients.
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