Evidence map›Paper›PMID 41171083›Full record

ArticlemBio2025

Pneumococcal H₂O₂ reshapes mitochondrial function and reprograms host cell metabolism.

Anna Scasny, Babek Alibayov, Ngoc Hoang, Ana G Jop Vidal, Kenichi Takeshita, Consuelo Bautista-Muñoz, Eva Bengten, Antonino Baez, Wei Li, Jonathan Hosler and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint RestrainingbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Anna ScasnyDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Babek AlibayovDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Ngoc HoangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Ana G Jop VidalDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Kenichi TakeshitaDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Consuelo Bautista-MuñozDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Eva BengtenDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Antonino BaezDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Wei LiDepartment of Physics, Emory University, Atlanta, Georgia, USA.
Jonathan HoslerDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Kurt WarnckeDepartment of Physics, Emory University, Atlanta, Georgia, USA.
Kristin S EdwardsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jorge E VidalDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0003-0573-5658

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
Sex differences in operant cocaine memoriesP20GM144041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ramona Moles · 2023 to 2026
$12.1M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Co(II) Radical Pair Dynamics in B12 Enzyme CatalysisR01GM142113 · NIGMS · EMORY UNIVERSITY · PI WARNCKE, KURT · 2020 to 2023
$1.3M
The oxidation of heme-carrying proteins in the pathophysiology of pneumococcal diseaseR01AI175461 · NIAID · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jorge Eugenio Vidal · 2024 to 2026
$1.2M
DISSEMINATION OF MACROLIDE RESISTANCE ELEMENTS IN STREPTOCOCCUS PNEUMONIAER21AI144571 · NIAID · UNIVERSITY OF MISSISSIPPI MED CTR · PI STEPHENS, DAVID S, TZENG, YIH-LING · 2019 to 2020
$397k
Electron Paramagnetic Resonance SpectrometerS10RR017767 · NCRR · EMORY UNIVERSITY · PI WARNCKE, KURT · 2003 to 2003
$261k
NCRR NIH HHS S10 RR017767NIAID NIH HHS R01 AI175461NIAID NIH HHS R21 AI144571NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20 GM121334NIGMS NIH HHS P20 GM144041NIGMS NIH HHS P30 GM149404NIGMS NIH HHS R01 GM142113
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Host-Pathogen InteractionsHydrogen PeroxideMitochondriaStreptococcus pneumoniaeA549 CellsCell LineCitric Acid CycleEpithelial CellsGlycolysisHumansPyruvate OxidaseHydrogen PeroxidePyruvate Oxidasehost-pathogen interactionsmitochondrial metabolismpneumoniaStreptococcus pneumoniaeWarburg effect

Identifiers

PMID41171083
PMCPMC12691681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.