Evidence map›Paper›PMID 41171075›Full record

ArticleJournal of neurochemistry2025

Evaluation of a New Riluzole-Based Compound VA945 on Sodium and Potassium Conductances Expressed by SH-SY5Y- Derived Neurons.

J Cazzola, F Talpo, G Faravelli, C Donati, S Maramai, M Saletti, G Giuliani, M Paolino, A Cappelli, M Anzini and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

J CazzolaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
F TalpoDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
G FaravelliDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
C DonatiDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
S MaramaiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
M SalettiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
G GiulianiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
M PaolinoDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
A CappelliDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
M AnziniDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
P SommiDepartment of Molecular Medicine, Human Physiology Unit, University of Pavia, Pavia, Italy.
A VitaliDepartment of Chemistry, University of Pavia, Pavia, Italy.
A SalaDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
A TruccoDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
G R BiellaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
P SpaiardiDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.ORCID 0000-0001-7418-180X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Riluzole (Rilutek), a derivative of benzothiazole, acts as a neuroprotective agent by inhibiting voltage-dependent sodium (Na

Indexed as

NeuronsNeuroprotective AgentsPotassium ChannelsRiluzoleSodium ChannelsCell Line, TumorDose-Response Relationship, DrugHumansMembrane PotentialsPatch-Clamp TechniquesPotassiumSodiumNeuroprotective AgentsPotassiumPotassium ChannelsRiluzoleSodiumSodium Channels

Identifiers

PMID41171075
PMCPMC12577522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.