Evidence map›Paper›PMID 41171060›Full record

ArticlemBio2025

Functional insight into cyclin-dependent kinase (CDK)7 via chemical inhibition of the priority fungal pathogen

Pooja Sethiya, Desmarini Desmarini, Bethany Grace Bowring, Kyle Cesar, Michael J Boucher, Angela L Wei, Hiten D Madhani, Ben Crossett, Angela Connelly, Catriona L Halliday and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pooja SethiyaCentre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.ORCID 0000-0001-6584-3912
Desmarini DesmariniCentre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Bethany Grace BowringCentre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Kyle CesarDepartment of Biochemistry and Biophysics, University of California, San Francisco, California, USA.
Michael J BoucherDepartment of Biochemistry and Biophysics, University of California, San Francisco, California, USA.
Angela L WeiDepartment of Biochemistry and Biophysics, University of California, San Francisco, California, USA.
Hiten D MadhaniDepartment of Biochemistry and Biophysics, University of California, San Francisco, California, USA.ORCID 0000-0001-7400-6657
Ben CrossettSydney Mass Spectrometry, University of Sydney, Camperdown, New South Wales, Australia.
Angela ConnellySydney Mass Spectrometry, University of Sydney, Camperdown, New South Wales, Australia.
Catriona L HallidayCentre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia.ORCID 0000-0002-0301-7110
Sharon C-A ChenFaculty of Medicine and Health, Sydney Institute for Infectious Diseases, University of Sydney, Camperdown, New South Wales, Australia.
Joey LaiScientific Platforms, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Koon Ho WongFaculty of Health Sciences, University of Macau, Macau SAR, China.ORCID 0000-0002-9264-5118
Julianne Teresa DjordjevicCentre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.ORCID 0000-0003-4207-4115

Funding

American Heart Association 24POST1194861National Health and Medical Research Council 1183939NIH HHS R01AI00272
6 · The paper itself

Abstract

Cyclin-dependent kinase (CDK)7 regulates the cell cycle and transcription in higher eukaryotes, but its function and the antifungal potential of CDK7 inhibitors remain unexplored in fungal pathogens. CDK7 inhibitors were identified to probe CDK7 function in the priority fungal pathogen, IMPORTANCE:

Indexed as

Antifungal AgentsCryptococcus neoformansCyclin-Dependent KinasesProtein Kinase InhibitorsCyclin-Dependent Kinase-Activating KinaseFungal ProteinsHumansAntifungal AgentsCDK7 protein, humanCyclin-Dependent Kinase-Activating KinaseCyclin-Dependent KinasesFungal ProteinsProtein Kinase InhibitorsCAK complexCDK7CDK7-IN-3cell cycleCryptococcus neoformansHog1MAPKmevociclibRNAPIIsamuraciclibsplicingSY-1365SY-5609transcription

Identifiers

PMID41171060
PMCPMC12691695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.