Evidence map›Paper›PMID 41171005›Full record

ArticlemSphere2025

Modeling immune responses of cattle to

Gesa Krueger, Brahmaiah Meesaragandla, Lea Schultze, Katharina Pape, Ulrike Zedler, Gabriele Stooß, Shah Faisal, Kati Franzke, Stefanie A Barth, Una Janke and 4 more

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gesa KruegerInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.ORCID 0009-0008-3255-0097
Brahmaiah MeesaragandlaInstitute of Biochemistry, University of Greifswald, Greifswald, Germany.
Lea SchultzeInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.
Katharina PapeInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.
Ulrike ZedlerInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.
Gabriele StooßInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.
Shah FaisalInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.
Kati FranzkeInstitute of Infectology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.ORCID 0000-0003-0827-5407
Stefanie A BarthInstitute of Molecular Pathogenesis, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Jena, Germany.
Una JankeInstitute of Biochemistry, University of Greifswald, Greifswald, Germany.
Stefan H E KaufmannMax Planck Institute for Infection Biology, Berlin, Germany.
Björn CorleisInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.
Mihaela DelceaInstitute of Biochemistry, University of Greifswald, Greifswald, Germany.
Anca DorhoiInstitute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Isle Riems, Germany.ORCID 0000-0003-1739-749X

Funding

Deutsche Forschungsgemeinschaft NFDI4ImmunoDeutsche Forschungsgemeinschaft "Research Training Group 2719"Land Mecklenburg-Vorpommern Landesgraduiertenförderung Mecklenburg-Vorpommern
6 · The paper itself

Abstract

Tuberculosis (TB) remains a threat for human and livestock health. Mycobacteria causing TB are host-adapted pathogens that occasionally spill over into other species. IMPORTANCE: Mycobacterial infections, including bovine tuberculosis (TB), have a profound impact on global health. This is exemplified by zoonotic TB in humans and animal TB, which is a life-threatening disease in livestock and wildlife. Mycobacteria cause the formation of granulomas, which significantly impact disease progression. Therefore, decoding granulomas is essential for an in-depth understanding of immune responses to mycobacteria. Conventional mouse models frequently fail to develop organized granulomas, and the procurement of samples from granulomatous lesions in cattle and humans is challenging, offering limited insights into the course of infection. Most

Indexed as

GranulomaMycobacterium bovisTuberculosis, BovineAnimalsCattleCytokinesLeukocytesMacrophagesCytokines3D modelcattlegranulomaimmunitymycobacteriatuberculosis

Identifiers

PMID41171005
PMCPMC12645956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.