Evidence map›Paper›PMID 41170971›Full record

ArticleJournal of virology2025

The neddylation of the RNA-dependent RNA polymerase 3D of Coxsackievirus B3 promotes viral replication.

Siwei Li, Yanyan Dong, Xuexuan Wang, Danxiang Feng, Tian Luan, Ziyuan Wang, Lexun Lin, Yang Chen, Yao Wang, Yanru Fei and 3 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Prevalence and Genomic Features of Aichivirus D in Yaks in Western China.Animals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siwei LiDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.ORCID 0009-0006-7891-6336
Yanyan DongDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Xuexuan WangDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Danxiang FengDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Tian LuanDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Ziyuan WangDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Lexun LinTeaching Center of Pathogenic Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yang ChenTeaching Center of Pathogenic Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yao WangDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yanru FeiDepartment of Microbiology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yan WangDepartment of Microbiology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Zhaohua ZhongDepartment of Microbiology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.ORCID 0000-0002-0778-5053
Wenran ZhaoDepartment of Cell Biology, The School of Basic Medical Sciences, Harbin Medical University, Harbin, China.ORCID 0000-0003-2495-5138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of Coxsackievirus B3 (CVB3), the causative pathogen for severe diseases such as myocarditis, pancreatitis, and meningitis, remains largely unknown. Neddylation, the covalent modification of proteins through the conjugation of NEDD8, a ubiquitin-like molecule, plays critical roles in regulating cellular activities. Our previous study demonstrated that 3D

Indexed as

Enterovirus B, HumanNEDD8 ProteinRNA-Dependent RNA PolymeraseVirus ReplicationCell LineCoxsackievirus InfectionsHEK293 CellsHost-Pathogen InteractionsHumansProtein Processing, Post-TranslationalNEDD8 ProteinNEDD8 protein, humanRNA-Dependent RNA PolymeraseCoxsackievirus BNEDD8posttranslational modificationRNA-dependent RNA polymerase 3Dtripartite motif-containing 4

Identifiers

PMID41170971
PMCPMC12646006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.