Evidence map›Paper›PMID 41170946›Full record

ArticleAntimicrobial agents and chemotherapy2025

Vacuolar-ATPase inhibitors are antimicrobial agents active against intracellular mycobacteria.

Leah Rankine-Wilson, Tirosh Shapira, Jake Felker, Matthew Christofferson, Henok Sahile, Joseph Chao, Houria Afshar, Raymond J Andersen, Jim Sun, Yossef Av-Gay

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leah Rankine-WilsonDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-0049-5408
Tirosh ShapiraDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-9790-4860
Jake FelkerDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0009-0000-0617-2987
Matthew ChristoffersonDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Henok SahileDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Joseph ChaoDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-1212-7570
Houria AfsharDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Raymond J AndersenDepartment of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
Jim SunDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-6873-6052
Yossef Av-GayDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-9547-0237

Funding

Canadian Institute of Health Research 152931CIHR PJT-162424CIHR PPE-185827Cystic Fibrosis Canada AWD-021084Natural Sciences and Engineering Research Council of Canada RGPIN-2020-04032
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mycobacterium tuberculosisVacuolar Proton-Translocating ATPasesAnimalsHumansMacrolidesMacrophagesMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium bovisTHP-1 Cellsbafilomycin A1MacrolidesVacuolar Proton-Translocating ATPasesacidificationbafilomycinhost-directed therapyMycobacterium tuberculosisPtpAv-ATPase

Identifiers

PMID41170946
PMCPMC12691628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.