Evidence map›Paper›PMID 41170852›Full record

ArticlemBio2025

A sulfur-containing nucleoside antibiotic from

Sangkeun Son, Negar Shahsavari, Thomas Privalsky, Bryson A Hawkins, Mi-Hyun Lee, Norman Pitt, Akira Iinishi, Raleb Taher, Nikita Gupta, Chandra Sekar Shankar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sangkeun SonDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-4574-288X
Negar ShahsavariDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Thomas PrivalskyDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Bryson A HawkinsDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Mi-Hyun LeeDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Norman PittDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Akira IinishiDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Raleb TaherDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Nikita GuptaDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Chandra Sekar ShankarDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Jaini PatelDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.
Kim LewisDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-1335-9982

Funding

Discovering antimicrobials acting against MDR pathogensR01AI170962 · NIAID · NORTHEASTERN UNIVERSITY · PI LEWIS, KIM · 2022 to 2025
$4.5M
600MHz NMR SpectrometerS10OD032452 · OD · NORTHEASTERN UNIVERSITY · PI GUO, JASON JIANXIN · 2022 to 2022
$1.6M
NIAID NIH HHS R01 AI170962NIH HHS S10 OD032452
6 · The paper itself

Abstract

We report the discovery of 4'-thiothymidine (4'sT), a sulfur-containing nucleoside antibiotic produced by the nematode symbiont

Indexed as

Anti-Bacterial AgentsNucleosidesPhotorhabdusSulfurThymidineDrug Resistance, BacterialEscherichia coliKlebsiella pneumoniaeMicrobial Sensitivity TestsMultigene FamilyAnti-Bacterial AgentsNucleosidesSulfurThymidineEscherichia colinatural antimicrobial productsnucleoside analogsPhotorhabdusthymidine kinase

Identifiers

PMID41170852
PMCPMC12691670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.